Insulin-like Growth Factor Receptor Inhibitors: Baby or the Bathwater?

Cyclolignans as inhibitors of the insulin-like growth factor-1 receptor and malignant cell growth.

The insulin-like growth factor-1 receptor (IGF-1R) plays a pivotal role in transformation, growth, and survival of malignant cells, and has emerged as a general and promising target for cancer treatment. However, no fully selective IGF-1R inhibitors have thus far been found. This is explained by the fact that IGF-1R is highly homologous to the insulin receptor, coinhibition of which may cause d...

Juvenile psoriatic arthritis: bathwater or baby?

In silico prediction of B cell epitopes of the extracellular domain of insulin-like growth factor-1 receptor

The insulin-like growth factor-1 receptor (IGF-1R) is a transmembrane receptor with tyrosine kinase activity. The receptor plays a critical role in cancer. Using monoclonal antibodies (MAbs) against the IGF-1R, typically blocks ligand binding and enhances down-regulation of the cell-surface IGF-1R. Some MAbs such as cixutumumab are under clinical trial investigation. Targeting multiple distinct...

The baby and the bathwater.

The use of digital versus film photography has been a topic of debate since the invention of digital cameras towards the end of the 20th Century. Both digital and film photography have advantages and drawbacks. Twenty-first century photography is dominated by digital operation, but the older photochemical methods continue to serve many users and applications. Please join us for this 4th present...

Clinical development of inhibitors of the insulin-like growth factor receptor in oncology.

The insulin-like growth factor I receptor (IGF-IR) pathway plays a major role in cancer growth, tumor cell survival and resistance to therapy. Ancillary evidence that targeting the IGF-IR may be useful in the treatment of cancer has been accumulating for almost two decades. Today, more than two dozen compounds have been developed and clinical trials are underway for at least 12 of those. The ab...